Spencer worked for Frank Casey in the Warner Bros. publicity office while attending the University of Chicago. He left University to travel throughout Asia—teaching ESL and working for Mother Teresa in Calcutta, India. He was a full-time comedy writer and filmmaker when his mother, a clinical psychotherapist, sparked his interest in cognitive psychology, which led to the publication of his hit book 'The Brain Mechanic' by Chicken Soup for the Soul' publisher HCI Books, Inc. In 2021, Spencer formed Brain Mechanic Films LLC to produce educational films & entertainment. He also teaches and consults for individuals and corporations, as well as lectures at New York University, in the Center for Global Affairs.